(E)-GABAB receptor antagonist 1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

(E)-GABAB 受体拮抗剂 1 降低 GABA 诱导的 IP3（三磷酸肌醇）产生，IC50 为 37.9 μM。

(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.(E)-GABAB receptor antagonist 1 is a trans-GABAB receptor antagonist 1. GABAB receptor antagonist 1 (compound 14) is a selective and negative allosteric modulator of GABAB (γ-Aminobutyric acid) receptors.(In Vitro):(E)-GABAB receptor antagonist 1 reduces the maximum effect of IP3 in HEK293 cells overexpressing GABAB receptor and Gqi9 protein induced by agonist GABA, but does not alter EC50.

(E)-GABAB receptor antagonist 1 (compound 14) decreases agonist GABA-induced maximal effect of IP3 production in HEK293 cells overexpressing GABAB receptors and Gqi9 proteins without changing the EC50.

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Others

Other Targets

Adenine phosphoribosyltransferase

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1611483-29-4

304.38

C18H24O4

>98% (HPLC)

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O=C(O)C(/C=C/C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)=O.[(E)]

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(-20℃)

With Ice Pack

≥ 2 years